Assay Detail
Functional
CHEMBL1665148
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Antiproliferative activity against HPV-transformed human C4I cells after 7 days by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C4I |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.77 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652465 | GS-9191 | 1.0 | 1 | 9.36 |
| CHEMBL223737 | GS-438 | -1.0 | 1 | 6.33 |
| CHEMBL223160 | — | — | 1 | 5.88 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652465 | GS-9191 | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL223737 | GS-438 | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL223160 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 3100.0 | nM | 5.51 |