Assay Detail
ADMET
CHEMBL1665156
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Antiproliferative activity against human lung fibroblast after 7 days by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.16 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652465 | GS-9191 | 1.0 | 1 | 8.13 |
| CHEMBL223737 | GS-438 | -1.0 | 1 | 6.54 |
| CHEMBL223160 | — | — | 1 | 5.32 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652465 | GS-9191 | EC50 | = | 7.44 | nM | 8.13 |
| CHEMBL223737 | GS-438 | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL223160 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 23500.0 | nM | 4.63 |