Assay Detail
Functional
CHEMBL1665374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 7.77 |
| CHEMBL1652417 | — | — | 1 | 7.00 |
| CHEMBL247772 | — | — | 1 | 6.22 |
| CHEMBL1652416 | — | — | 1 | 6.05 |
| CHEMBL522887 | — | — | 1 | 6.00 |
| CHEMBL1098695 | — | — | 1 | 5.52 |
| CHEMBL599883 | — | — | 1 | 5.30 |
| CHEMBL1652415 | — | — | 1 | 4.82 |
| CHEMBL1652425 | — | — | 1 | 4.57 |
| CHEMBL602365 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1652417 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL247772 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1652416 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL522887 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1098695 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL599883 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1652415 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1652425 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL602365 | — | IC50 | = | 39000.0 | nM | 4.41 |