Assay Detail
Functional
CHEMBL1667159
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Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.43 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.05 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.62 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.10 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.85 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 7.64 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.60 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.32 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 5.60 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL170 | QUININE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 8400.0 | nM | 5.08 |