Assay Detail
Functional
CHEMBL1669998
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Antagonist activity at angiotensin AT1 receptor
15
Total Activities
15
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 8.96 | 10.90 |
| IC50 | 2 | 9.07 | 9.40 |
| Kb | 1 | - | - |
| pD2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47177 | — | — | 1 | 10.90 |
| CHEMBL275875 | CL-329167 | — | 1 | 10.90 |
| CHEMBL34866 | — | — | 1 | 9.40 |
| CHEMBL9599 | SC-55634 | — | 1 | 9.30 |
| CHEMBL45927 | — | — | 1 | 9.30 |
| CHEMBL24224 | — | — | 1 | 8.74 |
| CHEMBL85595 | — | — | 1 | 8.70 |
| CHEMBL9642 | SC-52892 | — | 1 | 8.68 |
| CHEMBL9714 | SC-51895 | — | 1 | 8.65 |
| CHEMBL12909 | — | — | 1 | 8.50 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.48 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.20 |
| CHEMBL158794 | — | — | 1 | 6.90 |
| CHEMBL358335 | — | — | 1 | - |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47177 | — | Kd | = | 0.01259 | nM | 10.90 |
| CHEMBL275875 | CL-329167 | Kd | = | 0.01259 | nM | 10.90 |
| CHEMBL34866 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL9599 | SC-55634 | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL45927 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL24224 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL85595 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL9642 | SC-52892 | Kd | = | 2.089 | nM | 8.68 |
| CHEMBL9714 | SC-51895 | Kd | = | 2.239 | nM | 8.65 |
| CHEMBL12909 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL191 | LOSARTAN | Kd | = | 3.311 | nM | 8.48 |
| CHEMBL315021 | FORASARTAN | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL158794 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL358335 | — | Kb | = | 0.45 | nM | - |
| CHEMBL1016 | CANDESARTAN | pD2 | = | 9.97 | — | - |