Compound Detail
CHEMBL358335
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL358335 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFGOUCLZEVSODP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
465.0
MW (Da)
4.86
ALogP
6
HBA
2
HBD
107.4
PSA (Ų)
0.46
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor CHEMBL227 | Ki | 9.0 | 9.0 | 1.0 | 1 |
| Type-1 angiotensin II receptor B CHEMBL263 | Ki | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor B | Ki | = | 1.0 | nM | 9.0 | Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical me... | 1469703 |
| Type-1 angiotensin II receptor | Ki | = | 1.0 | nM | 9.0 | Binding affinity to angiotensin AT1 receptor | 21071232 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1469703 | 10.1021/jm00103a014 | Rattus norvegicus | 5 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Type-1 angiotensin II receptor | 4 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Rattus norvegicus | 2 |
| 1469703 | 10.1021/jm00103a014 | Type-1 angiotensin II receptor B | 1 |
| 1469703 | 10.1021/jm00103a014 | Oryctolagus cuniculus | 1 |
Data from ChEMBL 36 via Core Engine