Assay Detail
Binding
CHEMBL651553
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Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dihydropyrimidine angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.08 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358335 | — | — | 1 | 9.00 |
| CHEMBL145564 | — | — | 1 | 8.96 |
| CHEMBL141659 | — | — | 1 | 8.08 |
| CHEMBL343251 | — | — | 1 | 7.39 |
| CHEMBL145036 | — | — | 1 | 7.24 |
| CHEMBL342287 | — | — | 1 | 7.09 |
| CHEMBL145276 | — | — | 1 | 6.82 |
| CHEMBL424483 | — | — | 1 | 6.72 |
| CHEMBL145017 | — | — | 1 | 6.07 |
| CHEMBL143083 | — | — | 1 | 6.00 |
| CHEMBL343622 | — | — | 1 | 5.84 |
| CHEMBL144952 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358335 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL145564 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL141659 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL343251 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL145036 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL342287 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL145276 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL424483 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL145017 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL143083 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL343622 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL144952 | — | Ki | = | 1600.0 | nM | 5.80 |