Assay Detail
Binding
CHEMBL1670336
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Binding affinity to angiotensin AT1 receptor
18
Total Activities
18
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.01 | 8.85 |
| Ki | 4 | 8.23 | 9.00 |
| pKb | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358335 | — | — | 1 | 9.00 |
| CHEMBL157577 | — | — | 1 | 8.85 |
| CHEMBL279629 | L-159913 | — | 1 | 8.77 |
| CHEMBL1668007 | — | — | 1 | 8.33 |
| CHEMBL9599 | SC-55634 | — | 1 | 8.31 |
| CHEMBL85595 | — | — | 1 | 8.25 |
| CHEMBL275875 | CL-329167 | — | 1 | 8.22 |
| CHEMBL9642 | SC-52892 | — | 1 | 8.19 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.16 |
| CHEMBL9714 | SC-51895 | — | 1 | 7.92 |
| CHEMBL12909 | — | — | 1 | 7.80 |
| CHEMBL267056 | — | — | 1 | 7.77 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 7.68 |
| CHEMBL7396 | — | — | 1 | 7.66 |
| CHEMBL312104 | RIPISARTAN | 2.0 | 1 | 7.62 |
| CHEMBL1668003 | — | — | 1 | 7.54 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 6.96 |
| CHEMBL1668123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358335 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL157577 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL279629 | L-159913 | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1668007 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL9599 | SC-55634 | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL85595 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL275875 | CL-329167 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL9642 | SC-52892 | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL315021 | FORASARTAN | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL9714 | SC-51895 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL12909 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL267056 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL7396 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL312104 | RIPISARTAN | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1668003 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1668123 | — | pKb | = | 10.6 | — | - |