Compound Detail
CHEMBL312104
RIPISARTAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL312104 |
| Name | RIPISARTAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | OLJAPHMBAMBVKL-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
3
Known Names
Molecular Properties
426.5
MW (Da)
3.12
ALogP
7
HBA
2
HBD
117.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 4 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | Ki | 7.62 | 7.62 | 24.0 | 1 |
| Type-1 angiotensin II receptor CHEMBL227 | Ki | 7.62 | 7.62 | 24.0 | 1 |
| Type-1 angiotensin II receptor B CHEMBL263 | Ki | 7.62 | 7.62 | 24.0 | 1 |
| Type-2 angiotensin II receptor CHEMBL257 | Ki | 4.1 | 4.1 | 79200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor B | Ki | = | 24.0 | nM | 7.62 | Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) rece... | 8057285 |
| Angiotensin II receptor (AT-1) type-1 | Ki | = | 24.0 | nM | 7.62 | Binding affinity was evaluated towards Angiotensin II receptor, type 1 in rat ad... | 8576904 |
| Type-1 angiotensin II receptor | Ki | = | 24.0 | nM | 7.62 | Binding affinity to angiotensin AT1 receptor | 21071232 |
| Type-2 angiotensin II receptor | Ki | = | 79200.0 | nM | 4.1 | In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal | 8057285 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8057285 | 10.1021/jm00041a016 | Rattus norvegicus | 2 |
| 8057285 | 10.1021/jm00041a016 | Type-1 angiotensin II receptor B | 1 |
| 8057285 | 10.1021/jm00041a016 | Type-2 angiotensin II receptor | 1 |
| 8576904 | 10.1021/jm9504722 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 8576904 | 10.1021/jm9504722 | Oryctolagus cuniculus | 1 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Type-1 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine