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Assay Detail

CHEMBL650293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Type-2 angiotensin II receptor (CHEMBL257)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.
Nicolaï E, Curé G, Goyard J, Kirchner M, Teulon JM, Versigny A, Cazes M, Caussade F, Virone-Oddos A, Cloarec A.
J Med Chem (1994) 37 : 2371 -2386
PubMed 8057285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.10 4.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL312104 RIPISARTAN 2.0 1 4.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL312104 RIPISARTAN Ki = 79200.0 nM 4.10