Assay Detail
Binding
CHEMBL1670064
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Inhibition of human recombinant IKK2 in human PBMC
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 8.60 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669569 | — | — | 1 | 9.30 |
| CHEMBL1669608 | — | — | 1 | 9.30 |
| CHEMBL1669563 | — | — | 1 | 9.22 |
| CHEMBL1669562 | — | — | 1 | 9.22 |
| CHEMBL1669599 | — | — | 1 | 9.05 |
| CHEMBL1669565 | — | — | 1 | 9.00 |
| CHEMBL1669605 | — | — | 1 | 9.00 |
| CHEMBL1669596 | — | — | 1 | 8.96 |
| CHEMBL1669551 | — | — | 1 | 8.92 |
| CHEMBL1669603 | — | — | 1 | 8.89 |
| CHEMBL1669597 | — | — | 1 | 8.89 |
| CHEMBL1669600 | — | — | 1 | 8.85 |
| CHEMBL592893 | — | — | 1 | 8.80 |
| CHEMBL601079 | — | — | 1 | 8.72 |
| CHEMBL1669571 | — | — | 1 | 8.72 |
| CHEMBL1669601 | — | — | 1 | 8.70 |
| CHEMBL1669560 | — | — | 1 | 8.66 |
| CHEMBL1669595 | — | — | 1 | 8.66 |
| CHEMBL1669602 | — | — | 1 | 8.64 |
| CHEMBL1669604 | — | — | 1 | 8.60 |
| CHEMBL1669559 | — | — | 1 | 8.55 |
| CHEMBL1669568 | — | — | 1 | 8.55 |
| CHEMBL1669593 | — | — | 1 | 8.55 |
| CHEMBL1669552 | — | — | 1 | 8.52 |
| CHEMBL1669607 | — | — | 1 | 8.48 |
| CHEMBL1669554 | — | — | 1 | 8.46 |
| CHEMBL1669558 | — | — | 1 | 8.46 |
| CHEMBL1669555 | — | — | 1 | 8.43 |
| CHEMBL1669570 | — | — | 1 | 8.41 |
| CHEMBL1669572 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669569 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1669608 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1669563 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1669562 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1669599 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1669565 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1669605 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1669596 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1669551 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1669603 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1669597 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1669600 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL592893 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL601079 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1669571 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1669601 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1669560 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1669595 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1669602 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1669604 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1669559 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1669593 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1669568 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1669552 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1669607 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1669554 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1669558 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1669555 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1669570 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1669572 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1669567 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1669598 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1669556 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1669566 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1669561 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1669594 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1669573 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1669557 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1669606 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL1669564 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1669553 | — | IC50 | = | 14.0 | nM | 7.85 |