Compound Detail
CHEMBL1669606
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(N4CCN(Cc5cnn(CC(=O)N(CCO)CCO)c5)CC4)ncc3Cl)cc1-2
Basic Information
| ChEMBL ID | CHEMBL1669606 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHHWVKQXKIOMRP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
771.2
MW (Da)
2.51
ALogP
12
HBA
4
HBD
188.0
PSA (Ų)
0.14
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Inhibitor of nuclear factor kappa-B kinase subunit beta CHEMBL1991 | IC50 | 7.99 | 7.99 | 10.2 | 1 |
| PBMC CHEMBL613107 | IC50 | 6.32 | 6.32 | 474.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 4.0 | hr | Homo sapiens |
| T1/2 | 4.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Inhibitor of nuclear factor kappa-B kinase subunit beta | IC50 | = | 10.2 | nM | 7.99 | Inhibition of human recombinant IKK2 in human PBMC | 21236687 |
| PBMC | IC50 | = | 474.0 | nM | 6.32 | Inhibition of LPS-stimulated TNFalpha release in human PBMC | 21236687 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21236687 | 10.1016/j.bmc.2010.12.027 | Inhibitor of nuclear factor kappa-B kinase subunit beta | 3 |
| 21236687 | 10.1016/j.bmc.2010.12.027 | PBMC | 1 |
| 21236687 | 10.1016/j.bmc.2010.12.027 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine