Assay Detail
Binding
CHEMBL1670119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha after 80 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.34 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669154 | — | — | 1 | 7.16 |
| CHEMBL188678 | — | — | 1 | 6.89 |
| CHEMBL1669161 | — | — | 1 | 6.82 |
| CHEMBL1669160 | — | — | 1 | 6.82 |
| CHEMBL1669167 | — | — | 1 | 6.57 |
| CHEMBL1669159 | — | — | 1 | 6.54 |
| CHEMBL1669165 | — | — | 1 | 6.54 |
| CHEMBL1669155 | — | — | 1 | 6.52 |
| CHEMBL1669156 | — | — | 1 | 6.46 |
| CHEMBL1669166 | — | — | 1 | 6.40 |
| CHEMBL1669157 | — | — | 1 | 6.37 |
| CHEMBL1669158 | — | — | 1 | 6.33 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.30 |
| CHEMBL1669162 | — | — | 1 | 5.96 |
| CHEMBL1669163 | — | — | 1 | 5.82 |
| CHEMBL1669168 | — | — | 1 | 5.80 |
| CHEMBL1669169 | — | — | 1 | 5.52 |
| CHEMBL1669164 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669154 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL188678 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1669161 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1669160 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1669167 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1669159 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1669165 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1669155 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1669156 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1669166 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1669157 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1669158 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL98350 | LY-294002 | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1669162 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1669163 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1669168 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1669169 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1669164 | — | IC50 | = | 4400.0 | nM | 5.36 |