Assay Detail
Functional
CHEMBL1670618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 5-HT3 receptor in guinea pig ileum muscle
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new anti-depressants from structurally novel 5-HT3 receptor antagonists: design, synthesis and pharmacological evaluation of 3-ethoxyquinoxalin-2-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 6.16 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668031 | — | — | 1 | 7.70 |
| CHEMBL1668032 | — | — | 1 | 7.50 |
| CHEMBL1668036 | — | — | 1 | 7.20 |
| CHEMBL1668024 | — | — | 1 | 7.00 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 6.90 |
| CHEMBL1668034 | — | — | 1 | 6.90 |
| CHEMBL1668033 | — | — | 1 | 6.80 |
| CHEMBL1668025 | — | — | 1 | 6.80 |
| CHEMBL1668027 | — | — | 1 | 6.60 |
| CHEMBL1668026 | — | — | 1 | 6.00 |
| CHEMBL1668028 | — | — | 1 | 5.10 |
| CHEMBL1668037 | — | — | 1 | 5.00 |
| CHEMBL1668023 | — | — | 1 | 5.00 |
| CHEMBL1668029 | — | — | 1 | 4.80 |
| CHEMBL1668035 | — | — | 1 | 4.70 |
| CHEMBL1668030 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668031 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL1668032 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL1668036 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL1668024 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL46 | ONDANSETRON | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL1668034 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL1668033 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL1668025 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL1668027 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL1668026 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1668028 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL1668037 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL1668023 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL1668029 | — | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL1668035 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL1668030 | — | Kd | = | 25118.86 | nM | 4.60 |