Assay Detail
Binding
CHEMBL1670765
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Inhibition of human recombinant PDGFRalpha in cell free system after 60 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.49 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 9.62 |
| CHEMBL1668418 | — | — | 1 | 7.57 |
| CHEMBL1668414 | — | — | 1 | 7.06 |
| CHEMBL1668419 | — | — | 1 | 7.05 |
| CHEMBL1651523 | — | — | 1 | 6.36 |
| CHEMBL1668420 | — | — | 1 | 6.35 |
| CHEMBL1668412 | — | — | 1 | 5.92 |
| CHEMBL1668413 | — | — | 1 | 5.85 |
| CHEMBL1668415 | — | — | 1 | 5.64 |
| CHEMBL1668417 | — | — | 1 | 5.07 |
| CHEMBL1668416 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1668418 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1668414 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1668419 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1651523 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1668420 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1668412 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1668413 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1668415 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1668417 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1668416 | — | IC50 | = | 14000.0 | nM | 4.85 |