Assay Detail
Binding
CHEMBL1670767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant c-kit kinase in cell free system after 30 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 8.02 |
| CHEMBL1668419 | — | — | 1 | 5.89 |
| CHEMBL1668418 | — | — | 1 | 5.89 |
| CHEMBL1668420 | — | — | 1 | 5.85 |
| CHEMBL1668414 | — | — | 1 | 5.55 |
| CHEMBL1651523 | — | — | 1 | 5.39 |
| CHEMBL1668415 | — | — | 1 | 4.96 |
| CHEMBL1668413 | — | — | 1 | 4.33 |
| CHEMBL1668417 | — | — | 1 | 4.09 |
| CHEMBL1668416 | — | — | 1 | 4.00 |
| CHEMBL1668412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL1668419 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1668418 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1668420 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1668414 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1651523 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1668415 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1668413 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1668417 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL1668416 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1668412 | — | IC50 | > | 100000.0 | nM | - |