Assay Detail
Binding
CHEMBL1670830
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Inhibition of human recombinant VEGFR3 in cell free system after 90 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.83 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 9.30 |
| CHEMBL1668419 | — | — | 1 | 6.14 |
| CHEMBL1651523 | — | — | 1 | 5.92 |
| CHEMBL1668418 | — | — | 1 | 5.85 |
| CHEMBL1668420 | — | — | 1 | 5.80 |
| CHEMBL1668414 | — | — | 1 | 5.26 |
| CHEMBL1668415 | — | — | 1 | 5.24 |
| CHEMBL1668413 | — | — | 1 | 4.77 |
| CHEMBL1668417 | — | — | 1 | 4.19 |
| CHEMBL1668412 | — | — | 1 | - |
| CHEMBL1668416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1668419 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1651523 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1668418 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1668420 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1668414 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1668415 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1668413 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1668417 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL1668412 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1668416 | — | IC50 | > | 100000.0 | nM | - |