Assay Detail
Binding
CHEMBL1670834
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Inhibition of human recombinant MEK1 expressed in insect cells after 20 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 8.70 |
| CHEMBL1668419 | — | — | 1 | 4.92 |
| CHEMBL1651523 | — | — | 1 | 4.77 |
| CHEMBL1668418 | — | — | 1 | 4.66 |
| CHEMBL1668420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1668419 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1651523 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1668418 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1668420 | — | IC50 | > | 100000.0 | nM | - |