Assay Detail
Binding
CHEMBL1670880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acridone alkaloids as potent inhibitors of cathepsin V.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.82 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668599 | CITIBRASINE | — | 1 | 6.70 |
| CHEMBL1668597 | — | — | 1 | 6.30 |
| CHEMBL451705 | CITRUSININE-I | — | 1 | 6.00 |
| CHEMBL463652 | GLYCOCITRINE-IV | — | 1 | 5.96 |
| CHEMBL464846 | — | — | 1 | 5.92 |
| CHEMBL1668602 | — | — | 1 | 5.77 |
| CHEMBL465847 | CITRUSININE-II | — | 1 | 5.38 |
| CHEMBL1668601 | — | — | 1 | 5.36 |
| CHEMBL1668598 | GLYCOCITRINE-I | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668599 | CITIBRASINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1668597 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL451705 | CITRUSININE-I | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL463652 | GLYCOCITRINE-IV | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL464846 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1668602 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL465847 | CITRUSININE-II | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL1668601 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL1668598 | GLYCOCITRINE-I | Ki | = | 10000.0 | nM | 5.00 |