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Assay Detail

CHEMBL1671135

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to calf thymus DNA by ethidium bromide displacement assay
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Target

Calf thymus DNA (CHEMBL612514)
Type NUCLEIC-ACID
Organism Bos taurus

Publication

Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives.
Shibinskaya MO, Karpenko AS, Lyakhov SA, Andronati SA, Zholobak NM, Spivak NY, Samochina NA, Shafran LM, Zubritsky MJ, Galat VF.
Eur J Med Chem (2011) 46 : 794 -798
PubMed 21172726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.59 4.84
logKa 20 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1668375 2 4.84
CHEMBL1668382 2 4.84
CHEMBL1668381 2 4.84
CHEMBL1668377 2 4.80
CHEMBL1668379 2 4.73
CHEMBL1668376 2 4.69
CHEMBL1668378 2 4.51
CHEMBL1668380 2 4.48
CHEMBL1088346 2 4.08
CHEMBL1084905 2 4.06
CHEMBL1092507 2 -
CHEMBL1092508 2 -
CHEMBL1077006 2 -
CHEMBL1098374 2 -
CHEMBL1098689 2 -
CHEMBL1098690 2 -
CHEMBL1098691 2 -
CHEMBL493698 2 -
CHEMBL1088347 2 -
CHEMBL1084906 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1668375 IC50 = 14454.4 nM 4.84
CHEMBL1668382 IC50 = 14454.4 nM 4.84
CHEMBL1668381 IC50 = 14454.4 nM 4.84
CHEMBL1668377 IC50 = 15848.93 nM 4.80
CHEMBL1668379 IC50 = 18620.87 nM 4.73
CHEMBL1668376 IC50 = 20417.38 nM 4.69
CHEMBL1668378 IC50 = 30902.95 nM 4.51
CHEMBL1668380 IC50 = 33113.11 nM 4.48
CHEMBL1088346 IC50 = 83176.38 nM 4.08
CHEMBL1084905 IC50 = 87096.36 nM 4.06
CHEMBL1668378 logKa = 6.61 -
CHEMBL493698 IC50 = 165958.69 nM -
CHEMBL1668379 logKa = 6.83 -
CHEMBL1668380 logKa = 6.58 -
CHEMBL1668381 logKa = 6.94 -
CHEMBL1668382 logKa = 6.94 -
CHEMBL1092507 IC50 = 147910.84 nM -
CHEMBL1092508 IC50 = 107151.93 nM -
CHEMBL1077006 IC50 = 102329.3 nM -
CHEMBL1098374 IC50 = 151356.12 nM -
CHEMBL1098689 IC50 = 123026.88 nM -
CHEMBL1098690 IC50 = 112201.85 nM -
CHEMBL1098691 IC50 = 123026.88 nM -
CHEMBL1088347 IC50 = 131825.67 nM -
CHEMBL1084906 IC50 = 169824.37 nM -
CHEMBL1668377 logKa = 6.91 -
CHEMBL1668376 logKa = 6.79 -
CHEMBL1668375 logKa = 6.94 -
CHEMBL493698 logKa = 5.89 -
CHEMBL1084906 logKa = 5.87 -
CHEMBL1084905 logKa = 6.16 -
CHEMBL1088347 logKa = 5.98 -
CHEMBL1088346 logKa = 6.19 -
CHEMBL1098691 logKa = 6.01 -
CHEMBL1098690 logKa = 6.05 -
CHEMBL1098689 logKa = 6.01 -
CHEMBL1098374 logKa = 5.93 -
CHEMBL1092507 logKa = 5.93 -
CHEMBL1077006 logKa = 6.09 -
CHEMBL1092508 logKa = 6.07 -