Assay Detail
Functional
CHEMBL1671173
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Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.02 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47426 | — | — | 1 | 7.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | — | 1 | 6.66 |
| CHEMBL87982 | — | — | 1 | 6.28 |
| CHEMBL74590 | 7Z-3,4,4'-TRIMETHOXYSTILBENE | — | 1 | 5.64 |
| CHEMBL243684 | — | — | 1 | 5.64 |
| CHEMBL244944 | — | — | 1 | 5.47 |
| CHEMBL244727 | — | — | 1 | 5.29 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 5.24 |
| CHEMBL243446 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47426 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL87982 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL74590 | 7Z-3,4,4'-TRIMETHOXYSTILBENE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL243684 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL244944 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL244727 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL243446 | — | IC50 | = | 5900.0 | nM | 5.23 |