Assay Detail
Binding
CHEMBL1671585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for enzyme-inhibitor-substrate complex of human recombinant AChE by Lineweaver-Burk plot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.59 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 8.22 |
| CHEMBL464538 | — | — | 1 | 7.30 |
| CHEMBL1669494 | — | — | 1 | 6.12 |
| CHEMBL1669486 | — | — | 1 | 6.01 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 5.32 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL464538 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1669494 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL1669486 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | Ki | = | 12100000.0 | nM | - |