Assay Detail
Functional
CHEMBL1675304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human HeLa P4/R5 cells assessed as inhibition of viral replication
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.76 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 6.77 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.72 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.11 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.85 |
| CHEMBL578448 | — | — | 1 | 5.68 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.64 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 5.33 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.24 |
| CHEMBL4303288 | ABACAVIR SULFATE | 4.0 | 1 | 5.21 |
| CHEMBL590121 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL578448 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL991 | STAVUDINE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4303288 | ABACAVIR SULFATE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL590121 | — | IC50 | = | 10000.0 | nM | 5.00 |