Assay Detail
Functional
CHEMBL1675306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human PBMC assessed as inhibition of viral replication
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 9.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 7.85 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.52 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.00 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 7.00 |
| CHEMBL578448 | — | — | 1 | 6.72 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 6.70 |
| CHEMBL590121 | — | — | 1 | 6.44 |
| CHEMBL4303288 | ABACAVIR SULFATE | 4.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL991 | STAVUDINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL578448 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL853 | ZALCITABINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL590121 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4303288 | ABACAVIR SULFATE | IC50 | = | 910.0 | nM | 6.04 |