Assay Detail
Functional
CHEMBL1675365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiretroviral activity against Human immunodeficiency virus 1 NL4.3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.96 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.72 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.68 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.64 |
| CHEMBL259011 | — | — | 1 | 6.14 |
| CHEMBL19977 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL259011 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL19977 | — | EC50 | = | 24500.0 | nM | 4.61 |