Assay Detail
Functional
CHEMBL1675366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiretroviral activity against Human immunodeficiency virus 2 ROD infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.09 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.30 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.17 |
| CHEMBL259011 | — | — | 1 | 5.68 |
| CHEMBL19977 | — | — | 1 | 4.21 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584 | NELFINAVIR | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL259011 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL19977 | — | EC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL223228 | EFAVIRENZ | EC50 | > | 31680.0 | nM | - |