Assay Detail
Binding
CHEMBL1675411
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Displacement of [3H]PiB from human amyloid beta (1-42) at 100 nM after 180 mins by liquid scintillation counter
14
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging β-amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 12 | - | - |
| Ki | 2 | 8.07 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671878 | — | — | 2 | 8.24 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 2 | 7.89 |
| CHEMBL1672888 | — | — | 1 | - |
| CHEMBL1672889 | — | — | 1 | - |
| CHEMBL1672890 | — | — | 1 | - |
| CHEMBL1672891 | — | — | 1 | - |
| CHEMBL1672892 | — | — | 1 | - |
| CHEMBL1672893 | — | — | 1 | - |
| CHEMBL1672894 | — | — | 1 | - |
| CHEMBL1672895 | — | — | 1 | - |
| CHEMBL1672896 | — | — | 1 | - |
| CHEMBL1672897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671878 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Inhibition | = | 83.0 | % | - |
| CHEMBL1672888 | — | Inhibition | = | 82.0 | % | - |
| CHEMBL1672889 | — | Inhibition | = | 91.0 | % | - |
| CHEMBL1672890 | — | Inhibition | = | 91.0 | % | - |
| CHEMBL1672891 | — | Inhibition | = | 64.0 | % | - |
| CHEMBL1672892 | — | Inhibition | = | 91.0 | % | - |
| CHEMBL1672893 | — | Inhibition | = | 91.0 | % | - |
| CHEMBL1672894 | — | Inhibition | = | 86.0 | % | - |
| CHEMBL1672895 | — | Inhibition | = | 74.0 | % | - |
| CHEMBL1671878 | — | Inhibition | = | 97.0 | % | - |
| CHEMBL1672896 | — | Inhibition | = | 48.0 | % | - |
| CHEMBL1672897 | — | Inhibition | = | 73.0 | % | - |