Assay Detail
Functional
CHEMBL1675427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring reverse transcriptase L74V mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.54 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.68 |
| CHEMBL578448 | — | — | 1 | 5.54 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.08 |
| CHEMBL590121 | — | — | 1 | 4.86 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL578448 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL590121 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL141 | LAMIVUDINE | IC50 | - | — | - | |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | IC50 | - | — | - |