Assay Detail
Functional
CHEMBL1675630
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Antiviral activity of wild-type Human immunodeficiency virus 1 isolate 5331 by cell based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 11.00 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 11.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | - |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 0.00251 | nM | - |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.004 | nM | - |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.00044 | nM | - |