Assay Detail

CHEMBL1675632

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Functional

Antiviral activity of Human immunodeficiency virus 1 isolate 8116 harboring A98S, G190A mutation in reverse transcriptase by cell based assay

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.

Xu H, Quan Y, Brenner BG, Bar-Magen T, Oliveira M, Schader SM, Wainberg MA.
Antimicrob Agents Chemother (2009) 53 : 4667 -4672
PubMed 19704127 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	4	9.07	9.07

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL57	NEVIRAPINE	4.0	1	9.07
CHEMBL308954	ETRAVIRINE	4.0	1	-
CHEMBL70663	DAPIVIRINE	3.0	1	-
CHEMBL223228	EFAVIRENZ	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL57	NEVIRAPINE	EC50	=	0.852	nM	9.07
CHEMBL308954	ETRAVIRINE	EC50	=	0.00153	nM	-
CHEMBL70663	DAPIVIRINE	EC50	=	0.0001	nM	-
CHEMBL223228	EFAVIRENZ	EC50	=	0.00103	nM	-