Assay Detail
Functional
CHEMBL1675983
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Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.90 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673218 | — | — | 1 | 5.10 |
| CHEMBL1673217 | — | — | 1 | 5.06 |
| CHEMBL494897 | — | — | 1 | 5.00 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 4.80 |
| CHEMBL282748 | — | — | 1 | 4.52 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | - |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673218 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1673217 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL494897 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL282748 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | > | 200000.0 | nM | - |