Assay Detail
Functional
CHEMBL1676764
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Cytotoxicity against human HEK293 cells expressing human SERT assessed as decrease in cell viability after 48 hrs neutral red dye assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.51 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672014 | — | — | 1 | 4.90 |
| CHEMBL1165303 | — | — | 1 | 4.60 |
| CHEMBL1672016 | — | — | 1 | 4.60 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 4.60 |
| CHEMBL1672015 | — | — | 1 | 4.50 |
| CHEMBL1164191 | — | — | 1 | 4.50 |
| CHEMBL1165387 | — | — | 1 | 4.40 |
| CHEMBL1165775 | — | — | 1 | 4.00 |
| CHEMBL1672020 | — | — | 1 | - |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | - |
| CHEMBL1672019 | — | — | 1 | - |
| CHEMBL1672017 | — | — | 1 | - |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | - |
| CHEMBL1672018 | — | — | 1 | - |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672014 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL1165303 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1672016 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1672015 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL1164191 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL1165387 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL1165775 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1672020 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL6731 | TENAMFETAMINE | EC50 | = | 630957.34 | nM | - |
| CHEMBL1672019 | — | EC50 | = | 3981071.71 | nM | - |
| CHEMBL1672017 | — | EC50 | = | 5011872.34 | nM | - |
| CHEMBL43048 | MIDOMAFETAMINE | EC50 | = | 501187.23 | nM | - |
| CHEMBL1672018 | — | EC50 | = | 1584893.19 | nM | - |
| CHEMBL549 | CITALOPRAM | EC50 | = | 468.0 | nM | - |