Assay Detail
Functional
CHEMBL1676989
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2mef assessed as suppression of parasitemia by microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.86 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494897 | — | — | 1 | 6.23 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.85 |
| CHEMBL1673217 | — | — | 1 | 5.70 |
| CHEMBL1673218 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494897 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1673217 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1673218 | — | IC50 | = | 2200.0 | nM | 5.66 |