Assay Detail
Binding
CHEMBL1676997
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Inhibition of Plasmodium vivax GGPPS
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium vivax |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.78 | 4.89 |
| IC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494897 | — | — | 2 | 4.89 |
| CHEMBL1673217 | — | — | 2 | 4.82 |
| CHEMBL1673218 | — | — | 2 | 4.80 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 2 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494897 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1673217 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL1673218 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL923 | RISEDRONIC ACID | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 1100000.0 | nM | - |
| CHEMBL494897 | — | IC50 | = | 560000.0 | nM | - |
| CHEMBL1673217 | — | IC50 | = | 630000.0 | nM | - |
| CHEMBL1673218 | — | IC50 | = | 700000.0 | nM | - |