Assay Detail
Binding
CHEMBL1677388
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Inhibition of Trypanosoma cruzi Y PDEC after 30 mins
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cyclic nucleotide specific phosphodiesterase (CHEMBL1681621) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
Publication
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.38 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456617 | — | — | 1 | 5.66 |
| CHEMBL1673333 | — | — | 1 | 5.62 |
| CHEMBL457663 | — | — | 1 | 5.60 |
| CHEMBL458932 | — | — | 1 | 5.60 |
| CHEMBL456826 | — | — | 1 | 5.60 |
| CHEMBL455962 | — | — | 1 | 5.51 |
| CHEMBL458933 | — | — | 1 | 5.50 |
| CHEMBL511686 | — | — | 1 | 5.50 |
| CHEMBL1673316 | — | — | 1 | 5.48 |
| CHEMBL458296 | — | — | 1 | 5.46 |
| CHEMBL447757 | — | — | 1 | 5.46 |
| CHEMBL1673336 | — | — | 1 | 5.44 |
| CHEMBL1673321 | — | — | 1 | 5.42 |
| CHEMBL1673315 | — | — | 1 | 5.41 |
| CHEMBL509969 | — | — | 1 | 5.40 |
| CHEMBL1673325 | — | — | 1 | 5.39 |
| CHEMBL1673331 | — | — | 1 | 5.37 |
| CHEMBL1673334 | — | — | 1 | 5.35 |
| CHEMBL1673330 | — | — | 1 | 5.34 |
| CHEMBL458297 | — | — | 1 | 5.32 |
| CHEMBL460188 | — | — | 1 | 5.31 |
| CHEMBL456366 | — | — | 1 | 5.29 |
| CHEMBL457662 | — | — | 1 | 5.28 |
| CHEMBL456618 | — | — | 1 | 5.27 |
| CHEMBL1331520 | — | — | 1 | 5.26 |
| CHEMBL445832 | — | — | 1 | 5.25 |
| CHEMBL1673329 | GK03671 | — | 1 | 5.20 |
| CHEMBL456170 | — | — | 1 | 5.19 |
| CHEMBL1673326 | — | — | 1 | 5.16 |
| CHEMBL1503424 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456617 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1673333 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL458932 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL456826 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL457663 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL455962 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL458933 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL511686 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1673316 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL458296 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL447757 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1673336 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1673321 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1673315 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL509969 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1673325 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1673331 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1673334 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1673330 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL458297 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL460188 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL456366 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL457662 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL456618 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1331520 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL445832 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1673329 | GK03671 | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL456170 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1673326 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1503424 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1673318 | SCR 01311 | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL456574 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673312 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL443679 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL456327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL513099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673319 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1423543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673323 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673337 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673335 | — | IC50 | > | 10000.0 | nM | - |