Assay Detail
Binding
CHEMBL1679302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.41 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673049 | — | — | 1 | 6.89 |
| CHEMBL1673039 | — | — | 1 | 6.72 |
| CHEMBL1673043 | — | — | 1 | 6.70 |
| CHEMBL1673051 | — | — | 1 | 6.70 |
| CHEMBL1673053 | — | — | 1 | 6.70 |
| CHEMBL1673042 | — | — | 1 | 6.64 |
| CHEMBL1673052 | — | — | 1 | 6.64 |
| CHEMBL1673050 | — | — | 1 | 6.62 |
| CHEMBL1673046 | — | — | 1 | 6.62 |
| CHEMBL1673040 | — | — | 1 | 6.62 |
| CHEMBL1673041 | — | — | 1 | 6.58 |
| CHEMBL1673044 | — | — | 1 | 6.58 |
| CHEMBL1673045 | — | — | 1 | 6.55 |
| CHEMBL1673047 | — | — | 1 | 6.51 |
| CHEMBL1673048 | — | — | 1 | 6.50 |
| CHEMBL1673056 | — | — | 1 | 5.91 |
| CHEMBL1673055 | — | — | 1 | 5.88 |
| CHEMBL1673054 | — | — | 1 | 5.51 |
| CHEMBL1673057 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673049 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1673039 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1673043 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1673051 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1673053 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1673042 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1673052 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1673050 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1673046 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1673040 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1673041 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1673044 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1673045 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1673047 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1673048 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1673056 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1673055 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1673054 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1673057 | — | IC50 | = | 11380.0 | nM | 4.94 |