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Compound Detail

CHEMBL1673051

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CCN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1673051
Phase Preclinical
Structure Type MOL
InChI Key JGVXSQJYBQAPAE-UHFFFAOYSA-N
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

473.6
MW (Da)
3.73
ALogP
8
HBA
1
HBD
77.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H31N7O2
MW 473.58
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.33

Activity Summary

IC50 6 meas. best 7.28
EC50 1 meas. best 6.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Leucine-rich repeat serine/threonine-protein kinase 2
CHEMBL1075104
 IC50 7.28 7.26 52.0 2
Mitogen-activated protein kinase 7
CHEMBL5332
 IC50 7.18 7.02 66.0 3
Serine/threonine-protein kinase DCLK1
CHEMBL5683
 IC50 6.81 6.81 154.0 1
Mitogen-activated protein kinase 7
CHEMBL5332
 EC50 6.7 6.7 200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Leucine-rich repeat serine/threonine-protein kinase 2 IC50 = 52.0 nM 7.28 Inhibition of LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate i... 24239623
Leucine-rich repeat serine/threonine-protein kinase 2 IC50 = 57.0 nM 7.24 Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 r... 32530623
Mitogen-activated protein kinase 7 IC50 = 66.0 nM 7.18 Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5... 32530623
Mitogen-activated protein kinase 7 IC50 = 66.0 nM 7.18 Inhibition of N-terminal 6His-tagged human ERK5 expressed in baculovirus infecte... 24239623
Serine/threonine-protein kinase DCLK1 IC50 = 154.0 nM 6.81 Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 resid... 32530623
Mitogen-activated protein kinase 7 EC50 = 200.0 nM 6.7 Inhibition of EGF-stimulated ERK5 autophosphorylation in human HeLa cells preinc... 24239623
Mitogen-activated protein kinase 7 IC50 = 200.0 nM 6.7 Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PA... 21412406

Literature References

PubMed DOI Target Context # Activities
21412406 10.1021/ml100304b Mitogen-activated protein kinase 7 2
32530623 10.1021/acs.jmedchem.0c00596 Mitogen-activated protein kinase 7 2
24239623 10.1016/j.ejmech.2013.10.052 Mitogen-activated protein kinase 7 2
32530623 10.1021/acs.jmedchem.0c00596 Serine/threonine-protein kinase DCLK1 1
32530623 10.1021/acs.jmedchem.0c00596 Leucine-rich repeat serine/threonine-protein kinase 2 1
24239623 10.1016/j.ejmech.2013.10.052 Leucine-rich repeat serine/threonine-protein kinase 2 1

Data from ChEMBL 36 via Core Engine