Assay Detail
Binding
CHEMBL1679574
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Binding affinity to HIV1 reverse transcriptase by surface plasmon resonance based biosensor assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Deconstruction of non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 for exploration of the optimization landscape of fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 3.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317356 | — | — | 1 | 5.70 |
| CHEMBL316796 | — | — | 1 | 5.22 |
| CHEMBL1535399 | — | — | 1 | 4.52 |
| CHEMBL1087842 | — | — | 1 | 3.15 |
| CHEMBL1671951 | — | — | 1 | 3.10 |
| CHEMBL1671953 | — | — | 1 | 3.10 |
| CHEMBL1671952 | — | — | 1 | 2.96 |
| CHEMBL1580138 | — | — | 1 | 2.80 |
| CHEMBL1468531 | — | — | 1 | 2.77 |
| CHEMBL1671954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317356 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL316796 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL1535399 | — | Kd | = | 30000.0 | nM | 4.52 |
| CHEMBL1087842 | — | Kd | = | 700000.0 | nM | 3.15 |
| CHEMBL1671951 | — | Kd | = | 800000.0 | nM | 3.10 |
| CHEMBL1671953 | — | Kd | = | 800000.0 | nM | 3.10 |
| CHEMBL1671952 | — | Kd | = | 1100000.0 | nM | 2.96 |
| CHEMBL1580138 | — | Kd | = | 1600000.0 | nM | 2.80 |
| CHEMBL1468531 | — | Kd | = | 1700000.0 | nM | 2.77 |
| CHEMBL1671954 | — | Kd | = | 1300000.0 | nM | - |