Assay Detail
Binding
CHEMBL1679625
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Inhibition of human recombinant cathepsin S after 1 hr
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel cyanamide-based inhibitors of cathepsin C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.57 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672427 | — | — | 1 | 6.90 |
| CHEMBL1672425 | — | — | 1 | 6.50 |
| CHEMBL1672421 | — | — | 1 | 6.30 |
| CHEMBL1672434 | — | — | 1 | 6.00 |
| CHEMBL1672422 | — | — | 1 | 5.80 |
| CHEMBL1672419 | — | — | 1 | 5.80 |
| CHEMBL1672426 | — | — | 1 | 5.70 |
| CHEMBL1672432 | — | — | 1 | 5.40 |
| CHEMBL1672424 | — | — | 1 | 5.40 |
| CHEMBL1672420 | — | — | 1 | 5.10 |
| CHEMBL1672423 | — | — | 1 | 4.90 |
| CHEMBL1672430 | — | — | 1 | 4.80 |
| CHEMBL1672433 | — | — | 1 | 4.80 |
| CHEMBL262697 | CYANO-PYRROLIDINE | — | 1 | 4.60 |
| CHEMBL1672428 | — | — | 1 | - |
| CHEMBL1672429 | — | — | 1 | - |
| CHEMBL1672431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672427 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL1672425 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1672421 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL1672434 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1672422 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1672419 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1672426 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1672432 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1672424 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1672420 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1672423 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL1672430 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1672433 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL262697 | CYANO-PYRROLIDINE | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL1672428 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL1672429 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL1672431 | — | IC50 | > | 25118.86 | nM | - |