Assay Detail

CHEMBL1679747

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Binding

Binding affinity to progesterone receptor

ChEMBL ↗

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Target

Progesterone receptor (CHEMBL208) ↗

Open DB target context

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Primary target Progesterone receptor

CHEMBL208

Anchored from Assay target.

Protein identity Progesterone receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Progesterone receptor (CHEMBL208) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.

Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, Hattersley G.
ACS Med Chem Lett (2011) 2 : 124 -129
PubMed 24900290 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.91	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL103	PROGESTERONE	4.0	1	9.70
CHEMBL1672635	RAD-140	2.0	1	6.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL103	PROGESTERONE	IC50	=	0.2	nM	9.70
CHEMBL1672635	RAD-140	IC50	=	750.0	nM	6.12