Assay Detail
Binding
CHEMBL1680109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hr
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672327 | — | — | 1 | 8.00 |
| CHEMBL1672323 | — | — | 1 | 7.40 |
| CHEMBL1672328 | — | — | 1 | 7.05 |
| CHEMBL1672324 | — | — | 1 | 6.96 |
| CHEMBL1672326 | — | — | 1 | 6.96 |
| CHEMBL1672331 | — | — | 1 | 6.89 |
| CHEMBL1672330 | — | — | 1 | 6.66 |
| CHEMBL1672316 | — | — | 1 | 6.51 |
| CHEMBL1672314 | — | — | 1 | 6.43 |
| CHEMBL1672319 | — | — | 1 | 6.41 |
| CHEMBL1672321 | — | — | 1 | 6.35 |
| CHEMBL1672315 | — | — | 1 | 6.19 |
| CHEMBL1672320 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672327 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1672323 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1672328 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1672324 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1672326 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1672331 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1672330 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1672316 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1672314 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1672319 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1672321 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1672315 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1672320 | — | EC50 | = | 3300.0 | nM | 5.48 |