Assay Detail
Binding
CHEMBL1680618
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Displacement of [3H]methyltrienolone from human progesterone receptor expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.04 | 9.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672547 | — | — | 1 | 9.67 |
| CHEMBL1672541 | — | — | 1 | 9.53 |
| CHEMBL1672548 | — | — | 1 | 9.49 |
| CHEMBL1672545 | — | — | 1 | 9.10 |
| CHEMBL1672549 | — | — | 1 | 9.08 |
| CHEMBL1672546 | — | — | 1 | 8.84 |
| CHEMBL1672544 | — | — | 1 | 8.37 |
| CHEMBL1672543 | — | — | 1 | 7.55 |
| CHEMBL1672542 | — | — | 1 | 6.34 |
| CHEMBL235206 | — | — | 1 | 6.33 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | — | 1 | 6.32 |
| CHEMBL391231 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672547 | — | Ki | = | 0.214 | nM | 9.67 |
| CHEMBL1672541 | — | Ki | = | 0.298 | nM | 9.53 |
| CHEMBL1672548 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL1672545 | — | Ki | = | 0.795 | nM | 9.10 |
| CHEMBL1672549 | — | Ki | = | 0.834 | nM | 9.08 |
| CHEMBL1672546 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL1672544 | — | Ki | = | 4.23 | nM | 8.37 |
| CHEMBL1672543 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1672542 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL235206 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL391231 | — | Ki | = | 1230.0 | nM | 5.91 |