Assay Detail
Binding
CHEMBL1680621
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Displacement of [3H]methyltrienolone from human glucocorticoid receptor expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.71 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235206 | — | — | 1 | 8.23 |
| CHEMBL1672542 | — | — | 1 | 8.19 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | — | 1 | 7.30 |
| CHEMBL391231 | — | — | 1 | 7.26 |
| CHEMBL1672541 | — | — | 1 | 6.80 |
| CHEMBL1672547 | — | — | 1 | 6.28 |
| CHEMBL1672549 | — | — | 1 | 6.11 |
| CHEMBL1672544 | — | — | 1 | 6.03 |
| CHEMBL1672546 | — | — | 1 | 6.01 |
| CHEMBL1672545 | — | — | 1 | 5.82 |
| CHEMBL1672548 | — | — | 1 | 5.73 |
| CHEMBL1672543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235206 | — | Ki | = | 5.93 | nM | 8.23 |
| CHEMBL1672542 | — | Ki | = | 6.39 | nM | 8.19 |
| CHEMBL1672540 | 3-[(4-METHOXYPHENYL)PHENYLMETHYL]INDOLE | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL391231 | — | Ki | = | 54.4 | nM | 7.26 |
| CHEMBL1672541 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL1672547 | — | Ki | = | 523.0 | nM | 6.28 |
| CHEMBL1672549 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL1672544 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL1672546 | — | Ki | = | 977.0 | nM | 6.01 |
| CHEMBL1672545 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL1672548 | — | Ki | = | 1860.0 | nM | 5.73 |
| CHEMBL1672543 | — | Ki | > | 4290.0 | nM | - |