Assay Detail
Binding
CHEMBL1681079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of steroid sulfatase in human JEG-3 cells using [6,7-3H]E1S after 1 hr by scintillation spectrometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JEG-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.51 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672979 | — | — | 1 | 9.89 |
| CHEMBL1672978 | — | — | 1 | 9.08 |
| CHEMBL1672977 | — | — | 1 | 8.64 |
| CHEMBL592131 | — | — | 1 | 8.26 |
| CHEMBL1672976 | — | — | 1 | 7.77 |
| CHEMBL1672980 | — | — | 1 | 7.66 |
| CHEMBL598199 | — | — | 1 | 7.46 |
| CHEMBL108483 | — | — | 1 | 7.41 |
| CHEMBL1672981 | — | — | 1 | 7.26 |
| CHEMBL1672982 | — | — | 1 | 6.62 |
| CHEMBL430879 | — | — | 1 | 6.56 |
| CHEMBL1672974 | — | — | 1 | 5.54 |
| CHEMBL1672975 | — | — | 1 | 5.54 |
| CHEMBL108425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672979 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1672978 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL1672977 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL592131 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1672976 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1672980 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL598199 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL108483 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1672981 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1672982 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL430879 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL1672974 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1672975 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL108425 | — | IC50 | - | — | - |