Assay Detail
Binding
CHEMBL1685123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-pentazocine from Sigma1-receptor in guinea pig brain membrane
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.26 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.08 |
| CHEMBL408867 | [11C]SA4503 | — | 1 | 8.36 |
| CHEMBL1682086 | — | — | 1 | 6.23 |
| CHEMBL391153 | — | — | 1 | 6.06 |
| CHEMBL291439 | — | — | 1 | 6.05 |
| CHEMBL1682080 | — | — | 1 | 5.84 |
| CHEMBL1682083 | — | — | 1 | 5.68 |
| CHEMBL1682084 | — | — | 1 | 5.59 |
| CHEMBL1682085 | — | — | 1 | 5.35 |
| CHEMBL1682082 | — | — | 1 | 5.34 |
| CHEMBL1682081 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL408867 | [11C]SA4503 | Ki | = | 4.34 | nM | 8.36 |
| CHEMBL1682086 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL391153 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL291439 | — | Ki | = | 881.0 | nM | 6.05 |
| CHEMBL1682080 | — | Ki | = | 1442.0 | nM | 5.84 |
| CHEMBL1682083 | — | Ki | = | 2068.0 | nM | 5.68 |
| CHEMBL1682084 | — | Ki | = | 2564.0 | nM | 5.59 |
| CHEMBL1682085 | — | Ki | = | 4499.0 | nM | 5.35 |
| CHEMBL1682082 | — | Ki | = | 4521.0 | nM | 5.34 |
| CHEMBL1682081 | — | Ki | = | 5073.0 | nM | 5.29 |