Assay Detail
Functional
CHEMBL1685193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against X4 tropic HIV1 NL4.3 infected in CD4 and CXCR4 expressing human MT4 cells assessed as inhibition of viral cytopathicity
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.63 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682993 | — | — | 1 | 9.52 |
| CHEMBL1682866 | — | — | 1 | 9.40 |
| CHEMBL1682859 | — | — | 1 | 9.20 |
| CHEMBL1682986 | — | — | 1 | 8.96 |
| CHEMBL1682998 | — | — | 1 | 8.96 |
| CHEMBL1682997 | — | — | 1 | 8.85 |
| CHEMBL1682989 | — | — | 1 | 8.80 |
| CHEMBL1682996 | — | — | 1 | 8.80 |
| CHEMBL1682992 | — | — | 1 | 8.74 |
| CHEMBL1682865 | — | — | 1 | 8.68 |
| CHEMBL1682994 | — | — | 1 | 8.62 |
| CHEMBL1682857 | — | — | 1 | 8.54 |
| CHEMBL1682877 | — | — | 1 | 8.42 |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 8.32 |
| CHEMBL1682856 | — | — | 1 | 8.28 |
| CHEMBL1682995 | — | — | 1 | 8.11 |
| CHEMBL1682864 | — | — | 1 | 8.08 |
| CHEMBL1682991 | — | — | 1 | 7.82 |
| CHEMBL1099015 | — | — | 1 | 7.82 |
| CHEMBL1682858 | — | — | 1 | 7.77 |
| CHEMBL1682867 | — | — | 1 | 7.75 |
| CHEMBL1682987 | — | — | 1 | 7.74 |
| CHEMBL1682863 | — | — | 1 | 7.71 |
| CHEMBL1682854 | — | — | 1 | 7.63 |
| CHEMBL1682860 | — | — | 1 | 7.52 |
| CHEMBL1682874 | — | — | 1 | 7.47 |
| CHEMBL1682988 | — | — | 1 | 7.41 |
| CHEMBL1682872 | — | — | 1 | 7.39 |
| CHEMBL1682855 | — | — | 1 | 7.32 |
| CHEMBL1682990 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682993 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1682866 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1682859 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL1682986 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1682998 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1682997 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1682989 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1682996 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1682992 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1682865 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1682994 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1682857 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1682877 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1682856 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1682995 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL1682864 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1682991 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1099015 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL1682858 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1682867 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1682987 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL1682863 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL1682854 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL1682860 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1682874 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1682988 | — | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL1682872 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1682855 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL1682990 | — | IC50 | = | 48.1 | nM | 7.32 |
| CHEMBL1682862 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1682876 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL1682875 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL1682861 | — | IC50 | = | 553.0 | nM | 6.26 |
| CHEMBL1682868 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL1682879 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL1682871 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1682878 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1682870 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1682869 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1682873 | — | IC50 | > | 149200.0 | nM | - |