Assay Detail
Functional
CHEMBL1685197
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Antiviral activity against X4 tropic HIV1 NL4.3 infected in human PBMC assessed as inhibition of viral cytopathicity
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682997 | — | — | 1 | 8.70 |
| CHEMBL1682996 | — | — | 1 | 8.68 |
| CHEMBL1682998 | — | — | 1 | 8.68 |
| CHEMBL1682995 | — | — | 1 | 8.44 |
| CHEMBL1682994 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682997 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1682996 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1682998 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1682995 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1682994 | — | IC50 | = | 15.8 | nM | 7.80 |