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Assay Detail

CHEMBL1685454

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 6 days by Alamar blue assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.
Defaux J, Sala M, Formosa X, Galdeano C, Taylor MC, Alobaid WA, Kelly JM, Wright CW, Camps P, Muñoz-Torrero D.
Bioorg Med Chem (2011) 19 : 1702 -1707
PubMed 21315611 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.96 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1684455 1 5.46
CHEMBL1684453 1 5.17
CHEMBL536047 1 5.11
CHEMBL1684454 1 4.94
CHEMBL1684450 1 4.91
CHEMBL1684446 HUPRINE X HYDROCHLORIDE 1 4.90
CHEMBL539051 1 4.81
CHEMBL1684457 1 4.70
CHEMBL1684458 1 4.67
CHEMBL1684462 1 -
CHEMBL1684461 1 -
CHEMBL1684460 1 -
CHEMBL1684459 1 -
CHEMBL1684456 1 -
CHEMBL1684447 1 -
CHEMBL1684448 1 -
CHEMBL1684449 1 -
CHEMBL1684452 1 -
CHEMBL1684451 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1684455 IC50 = 3510.0 nM 5.46
CHEMBL1684453 IC50 = 6750.0 nM 5.17
CHEMBL536047 IC50 = 7800.0 nM 5.11
CHEMBL1684454 IC50 = 11600.0 nM 4.94
CHEMBL1684450 IC50 = 12400.0 nM 4.91
CHEMBL1684446 HUPRINE X HYDROCHLORIDE IC50 = 12500.0 nM 4.90
CHEMBL539051 IC50 = 15600.0 nM 4.81
CHEMBL1684457 IC50 = 20000.0 nM 4.70
CHEMBL1684458 IC50 = 21300.0 nM 4.67
CHEMBL1684462 IC50 - -
CHEMBL1684461 IC50 - -
CHEMBL1684460 IC50 - -
CHEMBL1684459 IC50 - -
CHEMBL1684456 IC50 - -
CHEMBL1684447 IC50 - -
CHEMBL1684448 IC50 - -
CHEMBL1684449 IC50 - -
CHEMBL1684452 IC50 - -
CHEMBL1684451 IC50 - -