Assay Detail
Functional
CHEMBL1686144
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Antiproliferative activity against human BT474 cells by methylene blue staining method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.28 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201179 | LAPATINIB DITOSYLATE | 4.0 | 1 | 7.00 |
| CHEMBL1683962 | — | — | 1 | 6.41 |
| CHEMBL1683964 | — | — | 1 | 6.19 |
| CHEMBL1683967 | — | — | 1 | 5.95 |
| CHEMBL1683974 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201179 | LAPATINIB DITOSYLATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1683962 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL1683964 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL1683967 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1683974 | — | IC50 | = | 1440.0 | nM | 5.84 |