Assay Detail

CHEMBL1686444

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Functional

Antiproliferative activity against human HCT116 cells expressing PI3Kalpha H1047R mutant

ChEMBL ↗

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Target

HCT-116 (CHEMBL394) ↗

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HCT-116 (CHEMBL394) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HCT-116

CHEMBL394

Anchored from Assay target.

Protein identity HCT-116

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-116
Confidence	1 — Organism
Curated By	Autocuration

Target

HCT-116 (CHEMBL394) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.

Ohwada J, Ebiike H, Kawada H, Tsukazaki M, Nakamura M, Miyazaki T, Morikami K, Yoshinari K, Yoshida M, Kondoh O, Kuramoto S, Ogawa K, Aoki Y, Shimma N.
Bioorg Med Chem Lett (2011) 21 : 1767 -1772
PubMed 21316229 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1684984	IZORLISIB	2.0	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1684984	IZORLISIB	IC50	=	200.0	nM	6.70